Over the last few decades, the engineering of nanoparticles has given rise to significant breakthroughs towards the employment of nanomaterials in biomedical applications, especially in drug delivery systems. Nanoparticles (NPs) have unique physical, optical, and electronic features, enabling the high degree of coincident transport and delivery of desired molecules or drugs within the biological systems.
The advantage of Nanoparticles (NPs)
Since NPs produced by nanotechnology are small enough, molecules capable of cellular entry through endocytosis or pinocytosis can be synthesized. With the advanced development of nanotechnology, NPs can be produced from various biocompatible materials, including lipids, polymers, and hybrid materials. In addition, NPs can be generated with desired size, shape and surface modifications, thereby effectively and stably delivering mRNA.
The advantages of NPs include
- Having higher saturation solubility and rapid dissolution
- Have a large particle surface
- Can be easily manipulated to achieve site-specific targeting
Despite the enormous potential of mRNA-based therapies, only recently has their therapeutic application become possible due to the considerable progress of nanomedicine in the design of non-viral vectors for gene delivery. Based on our advanced nanoparticle formulation development platform, Creative Biogene can fabricate a wide range of nanoparticles tailored with formulation development options, including lipid nanoparticles (LNPs), polymeric nanoparticles (PNPs), and lipid-polymer nanoparticles (LPNs). Creative Biogene is a dedicated service provider to produce mRNA delivery vectors. Our procedure is flexible, reproducible and the quality of nanoparticles can be guaranteed!
Our capabilities include
The first use of LNPs as a delivery vector for mRNA was reported in 2015. To date, LNPs have become the most developed method and highly effective for mRNA delivery. LNPs are comprised of various synthetic and naturally-derived lipids, which are the most commonly used materials for non-viral mRNA delivery. We can design and produce LNPs for mRNA delivery and screen administration routes.
Polymeric nanoparticles (PNPs)
In the last few years, polymeric nanoparticles (PNPs) have attracted considerable interest due to their unique properties and behaviors resulting from their small size. PNPs have many advantages when delivering mRNA, including intrinsic biocompatibility and biodegradability, lack of toxicity, easy surface modifications, and low cost of synthesis.
Lipid-polymer nanoparticles (LPNs)
Efficient delivery of mRNA is one of the key challenges. Suitable delivery systems are urgently needed to increase mRNA uptake. Lipid-polymer nanoparticles (LPNs) are evolving as a promising class of biomaterials for mRNA delivery, which integrate the physicochemical properties of both lipids and polymers. Our scientists have become experts in the field of mRNA delivery system development after years of experience. We are dedicated to offering optimal mRNA delivery vehicles to meet our clients' specific applications.
Advantage of our service
- Flexible, reproducible and scalable NPs manufacturing
- NPs production and optimization under strict quality control
- Target-oriented, customized mRNA delivery vector production
- One-stop solution with the most competitive price