mRNA Raw Materials

mRNA Raw Materials

In vitro synthesis of RNA is catalyzed by bacteriophage (SP6, T7 or T3) RNA polymerases using linear DNA as a template. Ribonucleoside triphosphates (NTPs) are the building blocks of these in vitro transcription reactions. Some naturally occuring RNAs such as messenger RNAs (mRNAs) or long non-coding RNAs (lncRNAs) contain a variety of modifications e.g. 5'-end guanosinemethylation (5'-Cap), 3'-end adenosine (poly(A) tail or several internal base modifications which markedly influence their biological function (e.g. translation efficiency, stability or immunogenicity). These structural features can be introduced during in vitro transcription via correspondingly modified NTPs and cap analoga to obtain biologically functional synthetic RNAs.

The SARS-CoV-2 pandemic has thrust mRNA therapeutics into the spotlight. From vaccines and immunotherapy to protein replacement and cell reprogramming, scientists' interest in mRNA manufacturing has exploded. Accelerated development of mRNA-based vaccines requires the conversion of standard research-grade in vitro transcription reagents into raw materials specifically designed and manufactured to advanced quality standards. As a global raw material supplier for mRNA, Creative Biogene helps you strengthen your supply chain, simplify the transition to manufacturing, ensure continuous production, and create consistently high-quality products.

The key to successful mRNA therapy starts with high-quality starting materials: mRNA reagents at a glance.

Enzyme & Related Buffer

Cat# Product Name Concentration/Size Inquiry
MRM-001 Ribonuclease Inhibitor, Human Placenta 40U/μL Inquiry
MRM-002 T7 RNA Polymerase, Low concentration 50U/μL Inquiry
MRM-003 T7 RNA Polymerase, High concentration 1000U/μL Inquiry
MRM-004 Vaccinia Capping Enzyme 10U/μL Inquiry
MRM-005 mRNA Cap-2'-O-Methyltransferase 50U/μL Inquiry
MRM-006 Pyrophosphatase Inorganic (yeast) 0.1U/μL Inquiry
MRM-007 DNase I (RNase-free) 1U/μL Inquiry
MRM-008 Poly(A) Polymerase 5U/μL Inquiry
MRM-009 BspQI 10U/μL Inquiry
MRM-010 RNase III 0.5U/μL Inquiry
MRM-011 T4 RNA ligase 1 10U/μL Inquiry


Cat# Product Name Concentration/Size Inquiry
MRM-012 ATP, Sodium Solution 100mM Inquiry
MRM-013 GTP, Sodium Solution 100mM Inquiry
MRM-014 CTP, Sodium Solution 100mM Inquiry
MRM-015 UTP, Sodium Solution 100mM Inquiry
MRM-016 ATP, Tris Salt Solution 200mM  Inquiry
MRM-017 GTP, Tris Salt Solution 200mM  Inquiry
MRM-018 CTP, Tris Salt Solution 200mM  Inquiry
MRM-019 UTP, Tris Salt Solution 200mM  Inquiry
MRM-020 5-Me-CTP 100mM Inquiry
MRM-021 pUTP 100mM Inquiry
MRM-022 N7-Me-GTP 100mM Inquiry
MRM-023 5-OMe-UTP 100mM Inquiry
MRM-024 5-OMe UTP, Tris Salt Solution 200mM Inquiry
MRM-025 N1-Me-pUTP 100mM Inquiry
MRM-026 N1-Me-pUTP, Tris Salt Solution 200mM Inquiry

Cap analog

Cat# Product Name Concentration/Size Inquiry
MRM-027 GpppG 100mM Inquiry
MRM-028 GpppA 100 mg Inquiry
MRM-029 M7-GpppA 5 mg Inquiry
For research use only. Not intended for any clinical use.
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