mRNA Vaccine Manufacturing


It has been nearly 100 years since the first application of vaccines. To date, the forms of vaccines are more extensive, including inactivated vaccines, attenuated vaccines, subunit vaccines, and polysaccharide vaccines. Since the first pre-clinical report in the 1990s, mRNA-based drugs have gradually received more attention as a new type of medicine. Compared with traditional vaccines, mRNA vaccines have greater advantages in terms of R&D and production, involving the short construction cycle, simple production technology as well as low transportation cost, and can be widely used in protein replacement therapy, tumor immunity and infectious disease.

Advantages of mRNA vaccines

The core principle behind mRNA vaccines is to deliver the transcript of interest, encoding one or more immunogens, into the host cell's cytoplasm, where the desired protein expression is located, secreted or intracellularly. mRNA vaccines show great potential and offer many advantages over conventional vaccines. The growing preclinical and clinical results demonstrate that mRNA vaccines are safe and tolerated in animal models and humans, bringing promises in infectious disease prophylaxis and tumor therapy. mRNA vaccines fulfill many aspects of an ideal clinical vaccine. The main advantages of mRNA vaccines include

  • Express a wide range of proteins: natural protein, antibody, virus protein, and others, breaking the existing patents and the limitations of virus strains.
  • High efficiency: Multiple modifications make the mRNA more stable and more easily translatable.
  • Safety: Because the mRNA vaccine is a non-infectious and non-integrated platform technology, there is no potential risk of infection or insertion of mutations. Besides, mRNA can be degraded by normal cells, and the half-life can be adjusted by modification.
  • Mass production and low cost: mRNA vaccines are amenable to rapid, inexpensive and scalable good manufacturing practice (GMP) production, largely due to the high efficiency of IVT mRNA production in vitro.

mRNA vaccines provided in Creative Biogene

According to categories of mRNA constructs

  • Conventional mRNA vaccines
  • Self-Amplify mRNA vaccines

According to types of delivery formats

  • Naked mRNA vaccines
  • Dendritic cell mRNA vaccines
  • Co-delivery of mRNA vaccines

Workflow of mRNA vaccine production

Workflow of mRNA vaccine production

Creative Biogene is a dedicated service provider in the field of mRNA-based drug research and development. We are committed to creating inventive services according to our customer's research goals. To better serve our global customers, we offer several forms of mRNA vaccines to meet the specific applications. Our manufacturing of mRNA vaccines is a promising novel platform that is highly flexible, scalable, and cost-effective.


  1. Jackson, N. A., et al. (2020). "The promise of mRNA vaccines: A biotech and industrial perspective." npj Vaccines, 5(1), 1-6.
  2. Zeng, C., et al. (2020). "Formulation and Delivery Technologies for mRNA Vaccines." 1-40.
For research use only. Not intended for any clinical use.
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